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It targets a specific region of the brain responsible for regulating appetite and food consumption

In the EU, patients and clinicians generally report to national competent authorities

Many patients struggle with appetite, cravings, insulin resistance, slow metabolism, hormonal changes, stress, poor sleep, and medical conditions that make weight loss more difficult

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IcoSema doses were adjusted in ten dose-step increments or decrements once weekly following a treat-to-target approach based on three pre-breakfast self-measured blood glucose (SMBG) values, measured on the 2 days before titration and on the day of titration (target SMBG: 4.47.2 mmol/l) (ESM Table 3)